Sid-Otmane Celia, Perrault Louis P, Ly Hung Q
Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.
Research Centre, Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada.
J Transl Med. 2020 Sep 1;18(1):336. doi: 10.1186/s12967-020-02504-8.
In the past decade, despite key advances in therapeutic strategies following myocardial infarction, none can directly address the loss of cardiomyocytes following ischemic injury. Cardiac cell-based therapy is at the cornerstone of regenerative medicine that has shown potential for tissue repair. Mesenchymal stem cells (MSC) represent a strong candidate to heal the infarcted myocardium. While differentiation potential has been described as a possible avenue for MSC-based repair, their secreted mediators are responsible for the majority of the ascribed prohealing effects. MSC can either promote their own survival and proliferation through autocrine effect or secrete trophic factors that will act on adjacent cells through a paracrine effect. Prior studies have also documented beneficial effects even when MSCs were remotely delivered, much akin to an endocrine mechanism. This review aims to distinguish the paracrine activity of MSCs from an endocrine-like effect, where remotely transplanted cells can promote healing of the injured myocardium.
在过去十年中，尽管心肌梗死后治疗策略取得了关键进展，但没有一种方法能够直接解决缺血性损伤后心肌细胞的丢失问题。基于心脏细胞的治疗是再生医学的基石，已显示出组织修复的潜力。间充质干细胞（MSC）是修复梗死心肌的有力候选者。虽然分化潜能被认为是基于MSC修复的一种可能途径，但其分泌的介质才是大部分归因的促愈合作用的原因。MSC可以通过自分泌作用促进自身存活和增殖，也可以分泌营养因子，通过旁分泌作用作用于相邻细胞。先前的研究还记录了即使远程递送MSC也有有益效果，这很类似于内分泌机制。本综述旨在区分MSC的旁分泌活性与类似内分泌的效应，即远程移植的细胞可以促进受损心肌的愈合。
