通过喷射注射进行皮内伤寒-破伤风联合疫苗接种。

Intradermal antityphoid-antitetanus vaccination by jet injection.

作者信息

Dimache G, Croitoru M, Velea V, Stoean C, Durbacă S, Mihăilescu M, Dimache A

机构信息

Contacuzino Institute, Bucharest, Romania.

出版信息

Roum Arch Microbiol Immunol. 1991 Apr-Jun;50(2):127-35.

PMID:1820189

Abstract

A lyophilized, heat-killed, phenol preserved typhoid vaccine (5 x 10(8) cells) suspended in 0.1 ml unadsorbed concentrated tetanus vaccine (10 Lf) was administered in man by intradermal route. This association of the two vaccines resulted in milder postvaccinal reactions: moreover, the immunological properties of typhoid vaccine, as certified by the passive protection test of the mouse with sera of the vaccines and the H and O agglutinin titres found in these immune sera, were perfectly conserved. Consequently, the mixed typhoid-tetanus vaccination in man by intradermal route is possible and advantageous for practical and economical reasons.

摘要

将冻干、热灭活、苯酚保存的伤寒疫苗（5×10⁸ 个菌细胞）悬浮于0.1 ml未吸附的浓缩破伤风疫苗（10Lf）中，通过皮内途径接种于人。两种疫苗联合使用导致疫苗接种后的反应较轻：此外，通过用疫苗血清对小鼠进行被动保护试验以及在这些免疫血清中发现的H和O凝集素效价所证实的伤寒疫苗的免疫学特性得到了完美保留。因此，出于实际和经济原因，通过皮内途径进行人用伤寒 - 破伤风联合疫苗接种是可行且有利的。