参与一项多中心预防试验的高危HIV感染者中失访的预测因素。
Predictors of attrition among high risk HIV-infected participants enrolled in a multi-site prevention trial.
作者信息
Johnson Mallory O, Dilworth Samantha E, Neilands Torsten B, Chesney Margaret A, Rotheram-Borus Mary Jane, Remien Robert H, Weinhardt Lance, Ehrhardt Anke A, Morin Stephen F
机构信息
University of California, 50 Beale Street, San Francisco, CA 94105, USA.
出版信息
AIDS Behav. 2008 Nov;12(6):974-7. doi: 10.1007/s10461-007-9356-y. Epub 2008 Jan 18.
Abstract
Retaining high-risk individuals is critical for HIV prevention trials. The current analyses examined predictors of trial dropout among HIV-infected men and women in a multi-site HIV prevention trial. Results indicated that dropouts (n = 74) were more likely to be younger, depressed, and not taking antiretroviral therapy (ART) than those who continued (n = 815). No other background, substance use, or transmission risk differences were found, suggesting no direct evidence of dropout bias on key outcomes. Efforts may be warranted for early detection and treatment of depression and for improving retention of younger participants and those not on ART.
摘要
留住高风险个体对于艾滋病预防试验至关重要。当前的分析研究了一项多中心艾滋病预防试验中感染艾滋病病毒的男性和女性退出试验的预测因素。结果表明，与继续参与试验的人（n = 815）相比，退出者（n = 74）更可能年龄较小、患有抑郁症且未接受抗逆转录病毒疗法（ART）。未发现其他背景、物质使用或传播风险方面的差异，这表明没有直接证据表明在关键结果上存在退出偏倚。或许有必要努力早期发现和治疗抑郁症，并提高年轻参与者以及未接受抗逆转录病毒疗法者的留存率。
相似文献
1
Predictors of attrition among high risk HIV-infected participants enrolled in a multi-site prevention trial.
AIDS Behav. 2008 Nov;12(6):974-7. doi: 10.1007/s10461-007-9356-y. Epub 2008 Jan 18.
2
Predictors of dropout from care among HIV-infected patients initiating antiretroviral therapy at a public sector HIV treatment clinic in sub-Saharan Africa.
BMC Infect Dis. 2016 Feb 1;16:43. doi: 10.1186/s12879-016-1392-7.
3
Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women.
Cochrane Database Syst Rev. 2010 Mar 17(3):CD008440. doi: 10.1002/14651858.CD008440.
4
Patient retention, clinical outcomes and attrition-associated factors of HIV-infected patients enrolled in Zimbabwe's National Antiretroviral Therapy Programme, 2007-2010.
PLoS One. 2014 Jan 29;9(1):e86305. doi: 10.1371/journal.pone.0086305. eCollection 2014.
5
Differences between completers and early dropouts from 2 HIV intervention trials: a health belief approach to understanding prevention program attrition.
Am J Public Health. 1998 Jul;88(7):1068-73. doi: 10.2105/ajph.88.7.1068.
6
Predictors of participation in an HIV risk reduction intervention for socially deprived Latino women: a cross sectional cohort study.
Int J Nurs Stud. 2006 Jul;43(5):527-34. doi: 10.1016/j.ijnurstu.2005.07.005. Epub 2005 Sep 8.
7
Antiretroviral treatment of HIV-1 prevents transmission of HIV-1: where do we go from here?
Lancet. 2013 Nov 2;382(9903):1515-24. doi: 10.1016/S0140-6736(13)61998-4. Epub 2013 Oct 23.
8
The Video intervention to Inspire Treatment Adherence for Life (VITAL Start): protocol for a multisite randomized controlled trial of a brief video-based intervention to improve antiretroviral adherence and retention among HIV-infected pregnant women in Malawi.
Trials. 2020 Feb 19;21(1):207. doi: 10.1186/s13063-020-4131-8.
9
Retention in care during the first 3 years of antiretroviral therapy for women in Malawi's option B+ programme: an observational cohort study.
Lancet HIV. 2016 Apr;3(4):e175-82. doi: 10.1016/S2352-3018(16)00008-4. Epub 2016 Mar 9.
10
Decentralising HIV treatment in lower- and middle-income countries.
Cochrane Database Syst Rev. 2013 Jun 27;2013(6):CD009987. doi: 10.1002/14651858.CD009987.pub2.
引用本文的文献
1
An Intervention by and for Transgender Women Living With HIV: Study Protocol for a Two-Arm Randomized Controlled Trial Testing the Efficacy of " to Improve HIV Care Outcomes.
Front Reprod Health. 2021 Oct 27;3:665723. doi: 10.3389/frph.2021.665723. eCollection 2021.
2
Recruitment and Retention of Women Living With HIV for Clinical Research: A Review.
AIDS Behav. 2021 Oct;25(10):3267-3278. doi: 10.1007/s10461-021-03273-1. Epub 2021 May 14.
3
Major depression disorder trajectories and HIV disease progression: results from a 6-year outpatient clinic cohort.
Medicine (Baltimore). 2018 Mar;97(12):e0252. doi: 10.1097/MD.0000000000010252.
4
Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries: a systematic review and meta-analysis.
Curr HIV/AIDS Rep. 2014 Sep;11(3):291-307. doi: 10.1007/s11904-014-0220-1.
5
Factors associated with study attrition among HIV-infected risky drinkers in St. Petersburg, Russia.
HIV Clin Trials. 2014 May-Jun;15(3):116-25. doi: 10.1310/hct1503-116.
6
Patterns and predictors of attrition in a trial of a housing intervention for homeless people with mental illness.
Soc Psychiatry Psychiatr Epidemiol. 2015 Feb;50(2):195-202. doi: 10.1007/s00127-014-0909-x. Epub 2014 Jun 12.
7
Using online social media for recruitment of human immunodeficiency virus-positive participants: a cross-sectional survey.
J Med Internet Res. 2014 May 1;16(5):e117. doi: 10.2196/jmir.3229.
8
Representativeness of an HIV cohort of the sites from which it is recruiting: results from the Ontario HIV Treatment Network (OHTN) cohort study.
BMC Med Res Methodol. 2013 Mar 5;13:31. doi: 10.1186/1471-2288-13-31.
9
Long-term dietary intervention trials: critical issues and challenges.
Trials. 2012 Jul 20;13:111. doi: 10.1186/1745-6215-13-111.
10
Subjective wellbeing and ‘felt’ stigma when living with HIV.
Qual Life Res. 2013 Feb;22(1):65-73. doi: 10.1007/s11136-012-0125-7.
本文引用的文献
1
The effect of adherence on the association between depressive symptoms and mortality among HIV-infected individuals first initiating HAART.
AIDS. 2007 May 31;21(9):1175-83. doi: 10.1097/QAD.0b013e32811ebf57.
2
Anxiety, depression, and cause-specific mortality: the HUNT study.
Psychosom Med. 2007 May;69(4):323-31. doi: 10.1097/PSY.0b013e31803cb862. Epub 2007 Apr 30.
3
Predictors of drop-out from an outpatient cardiac rehabilitation programme.
Clin Rehabil. 2007 Mar;21(3):222-9. doi: 10.1177/0269215506070771.
4
Effects of a behavioral intervention to reduce risk of transmission among people living with HIV: the healthy living project randomized controlled study.
J Acquir Immune Defic Syndr. 2007 Feb 1;44(2):213-21. doi: 10.1097/QAI.0b013e31802c0cae.
5
Correlates of nonparticipation in an HIV prevention program for MSM.
AIDS Educ Prev. 2006 Aug;18(4):348-61. doi: 10.1521/aeap.2006.18.4.348.
6
Human participants challenges in youth tobacco cessation research: researchers' perspectives.
Ethics Behav. 2004;14(4):321-34. doi: 10.1207/s15327019eb1404_4.
7
Recruiting and enrolling pregnant adolescents for research.
Issues Compr Pediatr Nurs. 2006 Jan-Mar;29(1):45-52. doi: 10.1080/01460860500523764.
8
Clinical trial recruitment and retention of a vulnerable population: HIV patients with chronic diarrhea.
Gastroenterol Nurs. 2005 Nov-Dec;28(6):463-8. doi: 10.1097/00001610-200511000-00002.
9
Recruitment and retention of adolescents in a smoking trajectory study: who participates and lessons learned.
Subst Use Misuse. 2006;41(2):175-82. doi: 10.1080/10826080500391704.
10
Latino recruitment and retention strategies: community-based HIV prevention.
J Immigr Health. 2001 Apr;3(2):97-105. doi: 10.1023/A:1009565900783.
Zotero 插件