Lam Hugh S, Ng Pak C
Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Pathology. 2008 Feb;40(2):141-8. doi: 10.1080/00313020701813735.
The use of biochemical markers in neonatal infection has remained an important area of research in the past decades. Many infection markers are components of the inflammatory cascade and reflect the host's immunological status and response to infection. Cytokines and chemokines such as interleukin (IL)-6 and IL-8 have been demonstrated to have good diagnostic utilities as early phase markers, while acute phase reactants such as C-reactive protein and procalcitonin have superior diagnostic properties during the later phases. Other markers, including inter-alpha-inhibitor proteins, IL-10 and regulated upon activation normal T cells expressed and secreted (RANTES) have been demonstrated to yield important prognostic information and may help the clinician identify infants who will develop fulminant infection from the outset of presentation. The advent of flow cytometry and molecular techniques have made crucial contributions to the field and promise to further improve the diagnostic accuracy and clinical management of infected infants.
在过去几十年里，生化标志物在新生儿感染中的应用一直是一个重要的研究领域。许多感染标志物是炎症级联反应的组成部分，反映了宿主的免疫状态和对感染的反应。细胞因子和趋化因子，如白细胞介素（IL）-6和IL-8，已被证明作为早期标志物具有良好的诊断效用，而急性期反应物，如C反应蛋白和降钙素原，在后期具有更好的诊断特性。其他标志物，包括α-抑制物蛋白、IL-10和活化正常T细胞表达和分泌调节因子（RANTES），已被证明能产生重要的预后信息，并可能帮助临床医生从发病之初就识别出将发生暴发性感染的婴儿。流式细胞术和分子技术的出现为该领域做出了至关重要的贡献，并有望进一步提高感染婴儿的诊断准确性和临床管理水平。
