Yang Chunyan, Liu Zhaoguo, Tian Min, Xu Ping, Li Baoyun, Yang Qiaozhi, Yang Yujun
Department of Peadiatric, Liaocheng People's Hospital, Liaocheng, Shandong, China (mainland).
Department of Peadiatric, Maternity and Child Care, Liaocheng, Shandong, China (mainland).
Med Sci Monit. 2016 Jan 9;22:92-8. doi: 10.12659/msm.895435.
We aimed to evaluate the clinical value of serum albumin levels for the evaluation and prognosis of late preterm infants with infections.
MATERIAL/METHODS: This was a retrospective study performed in late preterm infants admitted at the neonatal intensive care unit (NICU) of the Liaocheng People's Hospital between July 2012 and March 2013. Data, including laboratory test results, neonatal critical illness score (NCIS), perinatal complications and prognosis, were analyzed. The newborn infants were divided into 3 groups according to their serum albumin levels, (≥30 g/L, 25-30 g/L and ≤25 g/L for high, moderate, and low, respectively).
Among 257 patients, birth weight was 2003±348 g, gestational age was 35.7±2.3 weeks, and 59.1% were male. In addition, 127 (49.4%) were in the low albumin group. There were 32 patients with sepsis, 190 with infections, and 35 without infection, and their rates of hypoalbuminemia were 86.0%, 50.5%, and 30.7%, respectively (P<0.05). Albumin levels of the patients who survived were higher than those of the patients who died. In the low albumin group, the number of individual-event-critical NCIS cases and the frequency of multiple organs injuries were 63.8% and 28.3%, respectively, and were higher than in the 2 other groups. Mortality was higher in patients with sepsis. Hypoalbuminemia was associated with severe adverse outcomes (odds ratio=6.3, 95% confidence interval: 3.7-10.9, P<0.001).
Hypoalbuminemia was frequent among neonates with sepsis. Lower albumin levels might be associated with a poorer prognosis. Albumin levels could be appropriate for the diagnosis and prognosis of late preterm neonates with infections.
我们旨在评估血清白蛋白水平在晚期早产儿感染评估及预后判断中的临床价值。
材料/方法：这是一项回顾性研究，研究对象为2012年7月至2013年3月在聊城市人民医院新生儿重症监护病房（NICU）收治的晚期早产儿。分析了包括实验室检查结果、新生儿危重病例评分（NCIS）、围产期并发症及预后等数据。根据血清白蛋白水平将新生儿分为3组（高、中、低组分别为≥30 g/L、25 - 30 g/L和≤25 g/L）。
257例患者中，出生体重为2003±348 g，胎龄为35.7±2.3周，59.1%为男性。此外，127例（49.4%）在低白蛋白组。有32例败血症患者，190例感染患者，35例无感染患者，其低白蛋白血症发生率分别为86.0%、50.5%和30.7%（P<0.05）。存活患者的白蛋白水平高于死亡患者。在低白蛋白组，单项事件危重NCIS病例数及多器官损伤发生率分别为63.8%和28.3%，高于其他两组。败血症患者死亡率更高。低白蛋白血症与严重不良结局相关（比值比=6.3，95%置信区间：3.7 - 10.9，P<0.001）。
败血症新生儿中低白蛋白血症很常见。较低的白蛋白水平可能与较差的预后相关。白蛋白水平可用于晚期早产感染新生儿的诊断及预后判断。
