Sarmento Bruno, Martins Susana, Ferreira Domingos, Souto Eliana B
Department of Pharmaceutical Technology, Faculty of Pharmacy University of Porto, Porto, Portugal.
Int J Nanomedicine. 2007;2(4):743-9.
The aim of this work was to produce and characterize cetyl palmitate-based solid lipid nanoparticles (SLN) containing insulin, and to evaluate the potential of these colloidal carriers for oral administration. SLN were prepared by a modified solvent emulsification-evaporation method based on a w/o/w double emulsion. The particle size, zeta potential and association efficiency of unloaded and insulin-loaded SLN were determined and were found to be around 350 nm, negatively charged and the insulin association efficiency was over 43%. After oral administration of insulin-loaded SLN to diabetic rats, a considerable hypoglycemic effect was observed during 24 hours. These results demonstrated that SLN promote the oral absorption of insulin.
这项工作的目的是制备并表征含有胰岛素的十六烷基棕榈酸酯基固体脂质纳米粒（SLN），并评估这些胶体载体用于口服给药的潜力。基于水包油包水（w/o/w）双重乳液，通过改良的溶剂乳化蒸发法制备SLN。测定了未负载胰岛素和负载胰岛素的SLN的粒径、zeta电位和包封效率，发现粒径约为350 nm，带负电荷，胰岛素包封效率超过43%。将负载胰岛素的SLN口服给予糖尿病大鼠后，在24小时内观察到显著的降血糖作用。这些结果表明，SLN促进了胰岛素的口服吸收。
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