Pandey Sonia, Shaikh Farhinbanu, Gupta Arti, Tripathi Purnima, Yadav Jitendra Singh
Maliba Pharmacy College, Uka tarsadia University, Bardoli Mahuva Road, Surat 394350, Gujarat, India.
Department of Pharmaceutics, Bundelkhand University, Jhansi, U.P India.
Adv Pharm Bull. 2022 Jan;12(1):17-33. doi: 10.34172/apb.2022.007. Epub 2021 May 16.
Solid lipid nanoparticles (SLNs) are one of the developed technologies for addressing the bioavailability and targeting issues of drug delivery. In this review article, we attempted to incorporate all the essential details of SLNs like various methods of preparation, different models of SLNs, updated characterization methods, in vivo behavior (uptake), their applications, route of administration as well as advancements taken place in the field of delivery of biological drugs like gene vector, new adjuvant for vaccines, protein, and peptide with SLNs. Surface modified SLNs hold excellent potential for targeted and controlled drug delivery which is discussed and summarized. Based on the available data, the future success of SLNs is widened because they could be easily fabricated with various functionalities which would display enormous potential for targeting and diagnosing various diseases. This review would help the budding researchers to find out the unexplored areas of SLNs with the present discussion that reframes the potential of SLNs by gathering the various research findings of SLNs in tabular form along with the approved patent technologies of SLNs.
固体脂质纳米粒（SLNs）是为解决药物递送的生物利用度和靶向问题而开发的技术之一。在这篇综述文章中，我们试图纳入固体脂质纳米粒的所有基本细节，如各种制备方法、不同类型的固体脂质纳米粒、最新的表征方法、体内行为（摄取）、它们的应用、给药途径以及在生物药物递送领域（如基因载体、疫苗新佐剂、蛋白质和肽与固体脂质纳米粒）所取得的进展。表面修饰的固体脂质纳米粒在靶向和控释药物递送方面具有巨大潜力，对此进行了讨论和总结。基于现有数据，固体脂质纳米粒未来成功的可能性更大，因为它们可以很容易地制造出具有各种功能的产品，这将在靶向和诊断各种疾病方面显示出巨大潜力。这篇综述将帮助初出茅庐的研究人员通过当前的讨论找出固体脂质纳米粒尚未探索的领域，该讨论通过以表格形式收集固体脂质纳米粒的各种研究结果以及固体脂质纳米粒的已批准专利技术，重新界定了固体脂质纳米粒的潜力。
