惊叹于寄生虫的入侵。
MARveling at parasite invasion.
作者信息
Hager Kristin M, Carruthers Vern B
机构信息
Department of Biological Sciences, Center for Global Health and Infectious Disease, University of Notre Dame, Notre Dame, IN 46556-0369, USA.
出版信息
Trends Parasitol. 2008 Feb;24(2):51-4. doi: 10.1016/j.pt.2007.10.008. Epub 2008 Jan 18.
Abstract
Micronemal proteins (MICs) are key mediators of cytoadherence and invasion for Toxoplasma gondii. Emerging evidence indicates that carbohydrate binding facilitates Toxoplasma entry into host cells. The recently solved Toxoplasma MIC1s (TgMIC1s) structure reveals the presence of novel specialized domains that can discriminate between glycan residues. Comparison with Plasmodium erythrocyte-binding antigen 175 reveals that terminal sialic acid residues might represent a shared but tailored invasion pathway among apicomplexan parasites.
摘要
微线体蛋白（MICs）是刚地弓形虫细胞黏附和入侵的关键介质。新出现的证据表明，碳水化合物结合有助于弓形虫进入宿主细胞。最近解析的弓形虫MIC1s（TgMIC1s）结构揭示了存在可区分聚糖残基的新型特殊结构域。与疟原虫红细胞结合抗原175的比较表明，末端唾液酸残基可能代表了顶复门寄生虫之间共享但特定的入侵途径。
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