Fusamoto H, Suzuki K, Hayashi N, Sasaki Y, Kono M, Kasahara A, Kamada T
First Department of Medicine, Osaka University Medical School, Japan.
J Nutr Sci Vitaminol (Tokyo). 1991 Dec;37 Suppl:S71-7. doi: 10.3177/jnsv.37.supplement_s71.
We developed an in vivo ultrasonic attenuation measurement system with which we attempted to evaluate the degree of fatty infiltration in the liver. In an animal study, fatty liver was induced in rabbits, and ultrasonic radiofrequency waveforms from the liver were obtained using a 10 MHz A mode transducer. Frequency-dependent attenuation of the ultrasound, which was correlated with total lipid content, was calculated using a spectral difference method. In a human study, ultrasonic waveforms were obtained using a 3.5 MHz transducer. Frequency-dependent attenuation also showed a significant correlation with the grading of fatty infiltration of the liver. These results suggested that fatty infiltration of the liver could be evaluated quantitatively and noninvasively using frequency-dependent attenuation of the ultrasound.
我们开发了一种体内超声衰减测量系统，并用该系统尝试评估肝脏脂肪浸润程度。在一项动物研究中，诱导兔子患脂肪肝，使用10MHz A型换能器获取肝脏的超声射频波形。采用频谱差分法计算与总脂质含量相关的超声频率依赖性衰减。在一项人体研究中，使用3.5MHz换能器获取超声波形。频率依赖性衰减也与肝脏脂肪浸润分级显示出显著相关性。这些结果表明，利用超声的频率依赖性衰减可以对肝脏脂肪浸润进行定量和无创评估。
