Nicoll R G, Jackson M W, Knipp B S, Zagzebski J A, Steinberg H, O'Brien R T
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA.
Res Vet Sci. 1998 Jan-Feb;64(1):1-6. doi: 10.1016/s0034-5288(98)90106-0.
A study was designed to evaluate quantitative ultrasonographic characteristics of a diffuse parenchymal disease in an experimental model of subclinical fatty infiltration of the liver using diet-induced obesity and dietary restriction in the cat. Ultrasound images of livers were quantitatively analysed by a video signal analysis technique before, during and at the end of obesity induction, and then during and following dietary restriction. Attenuation and brightness (backscatter coefficient) were correlated with hepatic lipid content obtained from the livers by surgical and ultrasound-guided percutaneous biopsy. Attenuation and backscatter increased as hepatic lipid content increased. Both attenuation and backscatter significantly correlated with the hepatic lipid content (P=0.002 and P=0.02 respectively). This model of subclinical fatty infiltration of the liver in the cat demonstrates that hepatic lipid content increases as a consequence of obesity and of severe dietary restriction. Infiltration of the liver with fat may be evaluated non-invasively using quantitative ultrasonography by the video signal analysis technique. This method of image analysis may prove useful for the evaluation of diffuse parenchymal organ disease.
本研究旨在利用猫的饮食诱导肥胖和饮食限制，评估亚临床脂肪肝实验模型中弥漫性实质性疾病的定量超声特征。在肥胖诱导前、诱导期间和诱导结束时，以及饮食限制期间和之后，通过视频信号分析技术对肝脏超声图像进行定量分析。衰减和亮度（背散射系数）与通过手术和超声引导下经皮活检从肝脏获得的肝脂质含量相关。随着肝脂质含量增加，衰减和背散射增加。衰减和背散射均与肝脂质含量显著相关（分别为P = 0.002和P = 0.02）。猫的亚临床脂肪肝模型表明，肥胖和严格饮食限制会导致肝脂质含量增加。利用视频信号分析技术通过定量超声检查可对肝脏脂肪浸润进行无创评估。这种图像分析方法可能对弥漫性实质性器官疾病的评估有用。
