Karatza Ageliki A, Dimitriou Gabriel, Marangos Markos, Christofidou Myrto, Pavlou Vassiliki, Giannakopoulos Ioannis, Darzentas Antonios, Mantagos Stefanos P
Department of Paediatrics, Neonatal Intensive Care Unit, General University Hospital of Patras, 26504, Rio, Patras, Greece.
Eur J Pediatr. 2008 Sep;167(9):1021-3. doi: 10.1007/s00431-007-0634-5. Epub 2008 Jan 17.
This manuscript reports on two very low birth weight premature infants with respiratory distress, receiving parenteral nutrition and broad-spectrum antibiotics for about 3 weeks, who developed Candida albicans sepsis associated with fungal mycoses and endocarditis, despite treatment with Amphotericin B and Caspofungin. On days 40 and 47, respectively, antifungal therapy was modified to liposomal Amphotericin B combined with Fluconazole 6 mg/kg/day for 4 weeks, resulting in complete resolution of the mycetomas. Our observations suggest that the combination of liposomal Amphotericin B with Fluconazole is able to result in complete resolution of cardiac mycetomas in preterm infants.
本手稿报告了两名极低出生体重的早产婴儿，他们患有呼吸窘迫，接受肠外营养和广谱抗生素治疗约3周，尽管接受了两性霉素B和卡泊芬净治疗，但仍发生了与真菌性霉菌病和心内膜炎相关的白色念珠菌败血症。分别在第40天和第47天，抗真菌治疗改为脂质体两性霉素B联合氟康唑6mg/kg/天，持续4周，导致足菌肿完全消退。我们的观察结果表明，脂质体两性霉素B与氟康唑联合使用能够使早产儿的心脏足菌肿完全消退。
