Wallengren M L, Ericson D, Forsberg B, Johnson U
Department of Cariology, University of Lund, Malmö, Sweden.
Oral Microbiol Immunol. 1991 Oct;6(5):292-4. doi: 10.1111/j.1399-302x.1991.tb00495.x.
Mutans streptococci are well established as caries-inducing microorganisms in man. Most humans carry the bacteria, but in highly different numbers. This cannot be explained by environmental factors only. The aim of this study was to investigate a possible association between levels of colonization by mutans streptococci and the presence of certain B and DR human leukocyte antigens (HLA). Altogether, 170 subjects who had their HLA antigens determined (76 renal transplant patients and 94 healthy blood donors) were selected for the investigation. Paraffin-stimulated saliva samples were taken using the wooden spatula method with subsequent cultivation of mutans streptococci on mitis salivarius bacitracin agar plates. An association between the absence of HLA-DR 4 antigens and low, or undetectable, levels of mutans streptococci was found. This was statistically significant for the immunosuppressed renal transplant subjects. The same trend was observed among the healthy blood donors.
变形链球菌已被确认为人类致龋微生物。大多数人都携带这种细菌，但数量差异很大。这不能仅用环境因素来解释。本研究的目的是调查变形链球菌的定植水平与某些人类白细胞抗原B和DR（HLA）的存在之间可能存在的关联。总共选择了170名已确定HLA抗原的受试者（76名肾移植患者和94名健康献血者）进行调查。使用木质刮铲法采集石蜡刺激的唾液样本，随后在唾液链球菌杆菌肽琼脂平板上培养变形链球菌。发现HLA-DR 4抗原缺失与变形链球菌水平低或检测不到之间存在关联。这在免疫抑制的肾移植受试者中具有统计学意义。在健康献血者中也观察到了相同的趋势。
