Yildiz Mehmet, Pirim Ibrahim, Bayindir Yusuf Ziya, Olgun Hasim, Temel Fulya
Atatürk University, School of Dentistry, Department of Conservative Dentistry, Erzurum, Turkey.
Atatürk University, School of Medicine, Department of Medical Biology and Genetic, Erzurum, Turkey.
Eurasian J Med. 2009 Dec;41(3):146-8.
There have been reports of a relationship between human histocompatibility antigen types and increased incidence of dental caries. The association between specific patterns of HLA genetic inheritance is not clear and not well studied. The aim of the study was to investigate the relationship between MHC alleles and DMFT index in 65 teenagers.
Sixty-five teenagers were recruited from the students of elementary school of the university campus and the patients of the Ataturk University Dental School hospital. Low-resolution typing for the HLA-A, B, C and HLA-DR/DQ were performed by PCR-SSP method using SSP HLA class I generic DNA Typing Tray.
The results showed that HLA-DRB104 and -DRB107 frequencies were significantly higher (30.4% and 26.08% respectively) in DMFT≥1 group as compared with DMFT:0 group (10.5% and 5.26%), (p:0.168, OR:3.719; p:0.117, OR:6.353). Although frequencies of HLA-A2, -B27 and -B51 alleles were increased in DMFT≥1 group, they were not statically important. HLA-DRB111 were found to be more common in DMFT: 0 groups.
The pathogens involve in caries induce immune systems and response via the given HLA alleles could be important.
有报道称人类组织相容性抗原类型与龋齿发病率增加之间存在关联。HLA基因遗传的特定模式之间的关联尚不清楚且研究不足。本研究的目的是调查65名青少年中MHC等位基因与龋失补指数（DMFT）之间的关系。
从大学校园小学的学生和阿塔图尔克大学牙科学院医院的患者中招募了65名青少年。使用SSP HLA I类通用DNA分型试剂盒通过PCR-SSP方法对HLA-A、B、C和HLA-DR/DQ进行低分辨率分型。
结果显示，与DMFT为0的组（分别为10.5%和5.26%）相比，DMFT≥1的组中HLA-DRB104和-DRB107的频率显著更高（分别为30.4%和26.08%），（p：0.168，OR：3.719；p：0.117，OR：6.353）。虽然DMFT≥1的组中HLA-A2、-B27和-B51等位基因的频率有所增加，但在统计学上并不显著。发现HLA-DRB111在DMFT为0的组中更为常见。
参与龋齿的病原体诱导免疫系统，通过给定的HLA等位基因产生的反应可能很重要。
