Grassi M C, Nencini P, Paroli E
Istituto di Farmacologia Medica, Università degli Studi La Sapienza, Roma.
Ann Ist Super Sanita. 1991;27(4):671-4.
Although in several countries heroin addicts have been found to engage in illicit use of methadone, no studies have been addressed to this behavior in Italy. The present study gives evidence that methadone dispensed by public health services in Rome is paralleled by a black market in this drug. Of sixty-five heroin addicts hospitalized for medical or surgical problems, the majority (89.2%) referred to the existence of an illicit methadone market in Rome, and 38% used it. When asked why they bought illicit methadone the addicts stated that the daily dose obtainable from public health services was inadequate. However this statement is in contrast with the evidence that the heroin addicts using illicit methadone had highest daily doses similar to those of heroin addicts not referring to the illicit methadone market. We wonder whether illicit use of methadone is influenced by the therapeutic benefit that addicts expect to obtain from methadone. These "expectations" may lead heroin addicts to extend consumption of methadone to alleviate problems altogether unrelated to the withdrawal syndrome. If so, the illicit market in methadone may be sustained not by the drug's addictive properties but by its therapeutic effects.
尽管在一些国家已发现海洛因成瘾者非法使用美沙酮,但意大利尚未有针对此行为的研究。本研究表明,罗马公共卫生服务机构发放的美沙酮伴随着该药物的黑市交易。在因医疗或外科问题住院治疗的65名海洛因成瘾者中,大多数(89.2%)称罗马存在非法美沙酮市场,38%的人使用过。当被问及购买非法美沙酮的原因时,成瘾者表示从公共卫生服务机构获得的每日剂量不足。然而,这一说法与以下证据相矛盾:使用非法美沙酮的海洛因成瘾者的每日最大剂量与未提及非法美沙酮市场的海洛因成瘾者相似。我们想知道美沙酮的非法使用是否受成瘾者期望从美沙酮中获得的治疗益处的影响。这些“期望”可能导致海洛因成瘾者扩大美沙酮的用量,以完全缓解与戒断综合征无关的问题。如果是这样,美沙酮黑市的存在可能并非源于该药物的成瘾性,而是其治疗效果。