Forsburg Susan L
Molecular and Computational Biology Section, University of Southern California, 1050 Childs Way MCB 201B, Los Angeles, CA 90089-2910, USA.
Biochem Soc Trans. 2008 Feb;36(Pt 1):114-9. doi: 10.1042/BST0360114.
The MCM (minichromosome maintenance) complex is a helicase which is essential for DNA replication. Recent results suggest that the MCM helicase is important for replication fork integrity, and may function as a target of the replication checkpoint. Interactions between MCM proteins, checkpoint kinases, and repair and recovery proteins suggest that MCMs are proximal effectors of replication fork stability in the cell and are likely to play an important role in maintaining genome integrity.
微小染色体维持（MCM）复合物是一种解旋酶，对DNA复制至关重要。最近的研究结果表明，MCM解旋酶对复制叉的完整性很重要，可能作为复制检查点的一个靶点发挥作用。MCM蛋白、检查点激酶以及修复和恢复蛋白之间的相互作用表明，MCM是细胞中复制叉稳定性的近端效应器，可能在维持基因组完整性方面发挥重要作用。
