Pérez-Sola María José, Castón Juan José, Solana Rafael, Rivero Antonio, Torre-Cisneros Julián
Clinic Unit of Infectious Diseases, Reina Sofia University Hospital, Córdoba, Spain.
Enferm Infecc Microbiol Clin. 2008 Jan;26(1):38-47. doi: 10.1157/13114394.
Cytomegalovirus (CMV) infection is an important and frequent complication in solid organ transplant (SOT) recipients. This infection causes direct effects by viral inclusion in the cells of various tissues, as well as indirect effects by interaction between low levels of viremia and the host immune response. These indirect effects, such as increased incidence of graft rejection and opportunistic infections or decreased recipient survival, can be as severe as the direct effects, and thus require implementation of preventative practice guidelines. Universal prophylaxis against CMV has shown to be effective for preventing CMV disease and asymptomatic CMV replication, and can be considered the treatment of choice for preventing the indirect effects of this infection.
巨细胞病毒（CMV）感染是实体器官移植（SOT）受者中一种重要且常见的并发症。这种感染通过病毒包涵体存在于各种组织细胞中产生直接影响，同时也通过低水平病毒血症与宿主免疫反应之间的相互作用产生间接影响。这些间接影响，如移植排斥反应和机会性感染发生率增加或受者生存率降低，可能与直接影响一样严重，因此需要实施预防性实践指南。普遍预防CMV已被证明对预防CMV疾病和无症状CMV复制有效，可被视为预防这种感染间接影响的首选治疗方法。
