大鼠中普拉西泮和14C-普拉西泮的药代动力学特征。
Pharmacokinetic profiles of prazepam and 14C-prazepam in rat.
作者信息
Dios-Vieitez M C, Renedo M J, Fos D
机构信息
Departamento de Farmacia y Technologia Farmaceutica, Facultad de Farmacia, Universidad de Navarra, Spain.
出版信息
Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:3-8.
Pharmacokinetics of Prazepam and 14C-Prazepam were studied in rat. Prazepam was measured in blood and plasma by a gas-liquid chromatography assay with an electron capture detector. Its major metabolite, Desmethyldiazepam, was also determined in blood in the same way. Total radioactivity was measured in plasma by scintillation spectrometry. Pharmacokinetic analysis were carried out by two ways; according to compartmental pharmacokinetic models and by statistic moments.
在大鼠中研究了普拉西泮和14C-普拉西泮的药代动力学。通过带有电子捕获检测器的气液色谱分析法测定血液和血浆中的普拉西泮。其主要代谢产物去甲基地西泮也以同样的方式在血液中测定。通过闪烁光谱法测量血浆中的总放射性。药代动力学分析通过两种方式进行：根据房室药代动力学模型和统计矩。
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