吡罗昔康在大鼠体内的药代动力学。
Pharmacokinetics of piroxicam in rats.
作者信息
Fernandez-Troconiz J I, Lopez-Bustamante L G, Fos D
机构信息
Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Navarra, Pamplona, Spain.
出版信息
Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:80-4.
Pharmacokinetic of piroxicam was studied in the rat. Plasma and blood samples were analyzed by an high-performance liquid chromatography assay method. Plasma protein binding and blood to plasma concentration ratio were determined. Pharmacokinetic analysis was carried out fitting exponential equation to experimental data. All calculations were made using both JANA and PCNONLIN programs. This study reports a good estimation of the pharmacokinetic parameters of piroxicam in rats.
在大鼠中研究了吡罗昔康的药代动力学。通过高效液相色谱分析方法对血浆和血液样本进行分析。测定了血浆蛋白结合率和血药浓度与血浆浓度之比。通过将指数方程拟合到实验数据进行药代动力学分析。所有计算均使用JANA和PCNONLIN程序进行。本研究报告了对大鼠中吡罗昔康药代动力学参数的良好估计。
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