Hashimoto Shu, Matsumoto Ken, Gon Yasuhiro, Ichiwata Toshio, Takahashi Noriaki, Kobayashi Tomoko
Division of Respiratory Medicine, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Allergol Int. 2008 Mar;57(1):21-31. doi: 10.2332/allergolint.R-07-156. Epub 2008 Mar 1.
In bronchial asthma, respiratory virus infection involves several issues: 1) respiratory virus infection in infancy is a risk factor for, and may predispose to, the development of asthma later in life; 2) respiratory virus infection is associated with the acute exacerbation of bronchial asthma; and, 3) glucocorticosteroids (GC) are not adequate for controlling asthma-related symptoms upon respiratory virus infection. Various cells, inflammatory mediators and cytokines participate in the production of airway inflammation upon respiratory virus infection. Bronchial epithelial cells are a site of infection and replication of respiratory virus. They actively participate in the production of airway inflammation: 1) they produce various proinflammatory cytokines, chemokines and mediators; and, 2) they undergo apoptosis, thereby impairing the repair process. It is therefore important to understand the role of bronchial epithelial cells in the pathophysiology of bronchial asthma. In this review, the interaction between viral infection and asthma is discussed to elucidate the role of bronchial epithelial cells in viral infection.
在支气管哮喘中，呼吸道病毒感染涉及几个问题：1）婴儿期的呼吸道病毒感染是日后发生哮喘的一个危险因素，且可能使其易患哮喘；2）呼吸道病毒感染与支气管哮喘的急性加重相关；3）糖皮质激素（GC）不足以控制呼吸道病毒感染时的哮喘相关症状。多种细胞、炎症介质和细胞因子参与呼吸道病毒感染时气道炎症的产生。支气管上皮细胞是呼吸道病毒感染和复制的场所。它们积极参与气道炎症的产生：1）它们产生多种促炎细胞因子、趋化因子和介质；2）它们发生凋亡，从而损害修复过程。因此，了解支气管上皮细胞在支气管哮喘病理生理学中的作用很重要。在本综述中，将讨论病毒感染与哮喘之间的相互作用，以阐明支气管上皮细胞在病毒感染中的作用。
