Department of Immunology, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang 050017, Hebei, PR China.
Cytokine. 2011 Jan;53(1):1-7. doi: 10.1016/j.cyto.2010.09.011. Epub 2010 Oct 28.
Respiratory syncytial virus (RSV) is the primary cause of serious lower respiratory tract illness in infants and young children worldwide. The mechanism is largely unknown. RSV stimulates airway epithelial cells and resident leukocytes to release cytokines. Cytokines and chemokines involved in host response to RSV infection are thought to play a central role in the pathogenesis. In addition, RSV infection early in life has been associated with the development of asthma in later childhood. It is likely that the persistence of cytokines and chemokines in fully recovered patients with RSV in the long term can provide a substratum for the development of subsequent asthma. This review describes the genetic factors in cytokines and chemokines associated with severity of RSV disease, cytokines and chemokines synthesis in RSV infection, and the role of these innate immune components in RSV-associated asthma.
呼吸道合胞病毒（RSV）是全球婴儿和幼儿严重下呼吸道疾病的主要病因。其发病机制在很大程度上尚不清楚。RSV 可刺激气道上皮细胞和固有白细胞释放细胞因子。宿主对 RSV 感染反应中涉及的细胞因子和趋化因子被认为在发病机制中起核心作用。此外，生命早期 RSV 感染与以后儿童期哮喘的发生有关。很可能 RSV 完全康复患者体内细胞因子和趋化因子的持续存在为随后哮喘的发生提供了基质。这篇综述描述了与 RSV 疾病严重程度相关的细胞因子和趋化因子的遗传因素、RSV 感染中的细胞因子和趋化因子合成，以及这些固有免疫成分在 RSV 相关哮喘中的作用。
