Izzo E, Piccinino R, Caruso I, Bisogno A, Pesce G, Liberti A
III Divisione, Presidio Ospedaliero, D. Cotugno Specializzato in Malattie Infettive, USL 41, Regione Campania.
Riv Eur Sci Med Farmacol. 1991 May-Aug;13(3-4):173-7.
The authors have evaluated the efficacy of Fluconazole (400 mg/iv/die for three days and after 200 mg/iv/die for 18 days) in three AIDS and SNC Cryptococcal infection patients. Two patients have shown healing of meningeal syndrome and negative isolation after 21 days of therapy; one patient, however, died because of Cytomegalovirus pneumonia. It is of note that early spinal puncture in AIDS patients with neurological symptoms enables an early diagnosis and immediate therapy. Fluconazole treatment has been well tolerated and immediately effective to resolve two of the cases observed; the oral prophylaxis with 100 mg/die of Fluconazole after 6 months has been effective to prevent the relapses of the disease.
