Mullen William, Edwards Christine A, Serafini Mauro, Crozier Alan
Plant Products and Human Nutrition Group, Graham Kerr Building, Division of Environmental and Evolutionary Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
J Agric Food Chem. 2008 Feb 13;56(3):713-9. doi: 10.1021/jf072000p. Epub 2008 Jan 23.
Plasma and urine were collected over a 24 h period after the consumption by humans of 200 g of strawberries, containing 222 micromol of pelargonidin-3- O-glucoside, with and without cream. The main metabolite, a pelargonidin- O-glucuronide, reached a peak plasma concentration ( C max) of 274 +/- 24 nmol/L after 1.1 +/- 0.4 h ( t max) when only strawberries were ingested. When the strawberries were eaten with cream, the C max was not statistically different but the t max at 2.4 +/- 0.5 h was delayed significantly ( p < 0.001). The pelargonidin- O-glucuronide, along with smaller quantities of other metabolites, was also excreted in urine in quantities corresponding to ca. 1% of anthocyanin intake. The quantities excreted over the 0-24 h collection period were not influenced significantly by cream. However, the 0-2 h excretion of anthocyanin metabolites was significantly lower when the strawberries were eaten with cream, whereas the reverse occurred during with the 5-8 h excretion period. In keeping with these observations, measurement of plasma paracetamol and breath hydrogen revealed that cream delayed gastric emptying and extended mouth to cecum transit time.
在人类食用200克含有222微摩尔天竺葵素-3-O-葡萄糖苷的草莓（有无奶油搭配）后的24小时内收集血浆和尿液。仅食用草莓时，主要代谢产物天竺葵素-O-葡萄糖醛酸在1.1±0.4小时（达峰时间）后达到血浆峰值浓度（Cmax）274±24纳摩尔/升。当草莓与奶油一起食用时，Cmax无统计学差异，但达峰时间在2.4±0.5小时显著延迟（p<0.001）。天竺葵素-O-葡萄糖醛酸以及少量其他代谢产物也以相当于花青素摄入量约1%的量随尿液排出。在0至24小时收集期内排出的量不受奶油的显著影响。然而，当草莓与奶油一起食用时，花青素代谢产物在0至2小时的排泄量显著降低，而在5至8小时排泄期则相反。与这些观察结果一致，对血浆对乙酰氨基酚和呼气氢气的测量表明，奶油会延迟胃排空并延长口腔到盲肠的转运时间。
