使用微反应器促进有机卤化物与氢化锡和TTMSS的自由基反应。

Spurring radical reactions of organic halides with tin hydride and TTMSS using microreactors.

作者信息

Fukuyama Takahide, Kobayashi Masahide, Rahman Md Taifur, Kamata Naoya, Ryu Ilhyong

机构信息

Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.

出版信息

Org Lett. 2008 Feb 21;10(4):533-6. doi: 10.1021/ol702718z. Epub 2008 Jan 23.

DOI:10.1021/ol702718z

PMID:18211074

Abstract

Tributyltin hydride-mediated radical reactions of organic halides were successfully carried out in a continuous flow system using a microreactor. The reactions proceeded within a very short period of time, coupled with quickly decomposing radical initiators such as V-65 and V-70. The continuous flow reaction system was applied to gram scale synthesis of a key intermediate for furofuran lignans.

摘要

使用微反应器在连续流动体系中成功实现了有机卤化物的三丁基氢化锡介导的自由基反应。反应在极短时间内进行，同时能快速分解诸如V - 65和V - 70等自由基引发剂。该连续流动反应体系被应用于呋喃呋喃木脂素关键中间体的克级规模合成。