Manolikakes Georg, Gavryushin Andrei, Knochel Paul
Department Chemie und Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 Munich, Germany.
J Org Chem. 2008 Feb 15;73(4):1429-34. doi: 10.1021/jo702219f. Epub 2008 Jan 23.
A new silane-promoted nickel-catalyzed amination of aryl chlorides with 0.5 mol % of Ni(acac)2, 1 mol % of 3,5,6,8-tetrabromo-1,10-phenanthroline, and polymethylhydrosiloxane was developed. A broad range of aryl and heteroaryl chlorides can be coupled with secondary amines and anilines to give the desired (het)arylamines in good to excellent yields. The reaction is sensitive to the nature and amount of the silane promoter.
开发了一种新型硅烷促进的镍催化芳基氯与0.5摩尔%的Ni(acac)₂、1摩尔%的3,5,6,8-四溴-1,10-菲咯啉和聚甲基氢硅氧烷的胺化反应。多种芳基和杂芳基氯可以与仲胺和苯胺偶联，以良好至优异的产率得到所需的（杂）芳胺。该反应对硅烷促进剂的性质和用量敏感。
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