镍催化苯并恶唑与仲胺的 C-H 直接胺化反应。
Nickel-catalyzed C-H direct amination of benzoxazoles with secondary amines.
机构信息
State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, PR China.
出版信息
Org Biomol Chem. 2012 May 14;10(18):3715-20. doi: 10.1039/c2ob25425e. Epub 2012 Apr 3.
PMID:22495579
Abstract
In this article, a facile, efficient and practical method for Ni-catalyzed direct C-H amination of benzoxazole with secondary amines has been developed. This procedure requires Ni(OAc)(2)·4H(2)O as catalyst, TBHP as oxidant and acid as the additive. A variety of substituted benzoxazol-2-amines were synthesized in moderate to good yields.
摘要
本文开发了一种简便、高效、实用的 Ni 催化的苯并恶唑与仲胺的直接 C-H 胺化方法。该反应需要 Ni(OAc)(2)·4H(2)O 作为催化剂、TBHP 作为氧化剂和酸作为添加剂。该方法可以中等至良好的产率合成各种取代的苯并恶唑-2-胺。
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