State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, PR China.
Org Biomol Chem. 2012 May 14;10(18):3715-20. doi: 10.1039/c2ob25425e. Epub 2012 Apr 3.
In this article, a facile, efficient and practical method for Ni-catalyzed direct C-H amination of benzoxazole with secondary amines has been developed. This procedure requires Ni(OAc)(2)·4H(2)O as catalyst, TBHP as oxidant and acid as the additive. A variety of substituted benzoxazol-2-amines were synthesized in moderate to good yields.
本文开发了一种简便、高效、实用的 Ni 催化的苯并恶唑与仲胺的直接 C-H 胺化方法。该反应需要 Ni(OAc)(2)·4H(2)O 作为催化剂、TBHP 作为氧化剂和酸作为添加剂。该方法可以中等至良好的产率合成各种取代的苯并恶唑-2-胺。
