自然种群中连锁图谱的稳健性：一项模拟研究。
Robustness of linkage maps in natural populations: a simulation study.
作者信息
Slate Jon
机构信息
Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
出版信息
Proc Biol Sci. 2008 Mar 22;275(1635):695-702. doi: 10.1098/rspb.2007.0948.
Abstract
In a number of long-term individual-based studies of vertebrate populations, the genealogical relationships between individuals have been established with molecular markers. As a result, it is possible to construct genetic linkage maps of these study populations by examining the co-segregation of markers through the pedigree. There are now four free-living vertebrate study populations for whom linkage maps have been built. In this study, simulation was used to investigate whether these linkage maps are likely to be accurate. In all four populations, the probability of assigning markers to the correct chromosome is high and framework maps are generally inferred correctly. However, genotyping error can result in incorrect maps being built with very strong statistical support over the correct order. Future applications of linkage maps of natural populations are discussed.
摘要
在一些基于个体的脊椎动物种群长期研究中，已通过分子标记确定了个体间的谱系关系。因此，通过系谱检查标记的共分离情况，有可能构建这些研究种群的遗传连锁图谱。目前已有四个自由生活的脊椎动物研究种群构建了连锁图谱。在本研究中，通过模拟来调查这些连锁图谱是否可能准确。在所有四个种群中，将标记分配到正确染色体的概率很高，并且框架图谱通常能正确推断。然而，基因分型错误可能导致构建出错误的图谱，且在正确顺序上有非常强的统计支持。文中还讨论了自然种群连锁图谱的未来应用。
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