Bornstein R A, Baker G B
Department of Psychiatry, Ohio State University, Columbus 43210.
J Neuropsychiatry Clin Neurosci. 1991 Fall;3(4):417-21. doi: 10.1176/jnp.3.4.417.
Patients with Tourette's syndrome (TS) were grouped on the basis of levels of urinary phenylethylamine (PEA). These groups of TS patients were compared on an extensive battery of neuropsychological measures converted to age-corrected T scores based on published normative data. Patients with PEA levels below that of normal controls performed significantly worse than TS patients with normal PEA levels. The data were interpreted to suggest that abnormalities in PEA may contribute to neuropsychological deficits. Furthermore, these data may provide further support for an etiological subgroup of TS patients characterized by an abnormality in PEA metabolism. These data are discussed in regard to directions for further investigation.
患有妥瑞氏症（TS）的患者根据尿中苯乙胺（PEA）水平进行分组。基于已发表的常模数据，将这些妥瑞氏症患者组在一系列广泛的神经心理学测量指标上进行比较，并将其转换为年龄校正T分数。PEA水平低于正常对照组的患者在神经心理学表现上显著差于PEA水平正常的妥瑞氏症患者。这些数据被解释为表明PEA异常可能导致神经心理学缺陷。此外，这些数据可能为以PEA代谢异常为特征的妥瑞氏症患者病因亚组提供进一步支持。针对进一步研究的方向对这些数据进行了讨论。
