Bornstein R A, Baker G B
Neuropsychology Laboratory, Ohio State University, Columbus 43210.
Psychiatry Res. 1990 Mar;31(3):279-86. doi: 10.1016/0165-1781(90)90097-o.
Previous data indicated a subgroup of Tourette's syndrome patients with a beta-phenylethylamine (PEA) level that was lower than all subjects in a control group matched for age and education. The current study compared the subgroups of Tourette's syndrome patients (n = 28) from the previous study with 20 control subjects in regard to other amines and metabolites. Patients with low levels of PEA were also found to have lower levels of 3-methoxy-4-hydroxy-phenylglycol, normetanephrine, serotonin, m-tyramine, and p-tyramine. There was also some evidence of dopaminergic abnormalities in the low-PEA subgroup. These data provide suggest a role of PEA in the pathophysiology of some patients with Tourette's syndrome. This effect may be mediated through other neurotransmitter systems.
先前的数据表明，抽动秽语综合征患者中有一个亚组，其β-苯乙胺（PEA）水平低于年龄和教育程度相匹配的对照组中的所有受试者。当前的研究将先前研究中的抽动秽语综合征患者亚组（n = 28）与20名对照受试者在其他胺类和代谢产物方面进行了比较。还发现PEA水平低的患者3-甲氧基-4-羟基苯乙二醇、去甲变肾上腺素、血清素、间酪氨酸和对酪氨酸的水平也较低。在低PEA亚组中也有一些多巴胺能异常的证据。这些数据表明PEA在一些抽动秽语综合征患者的病理生理学中起作用。这种作用可能是通过其他神经递质系统介导的。
