Rathore K S, Kumar P, Jadhav U, Tendolkar A G
Department of Cardiovascular and Thoracic Surgery, Lokmanya Tilak Medical College and Hospital, Sion, Mumbai, India. kaushalendra_rathore @hotmail.com
J Cardiovasc Surg (Torino). 2008 Feb;49(1):119-24.
Rheumatic mitral patients reach their fifth decade of life more often now than in the past. The purpose of this study is to provide insight into improving morbidity and mortality in these patients.
This retrospective study included 105 patients aged 50 years or more. Seventy-five underwent mechanical valve replacement and 30 received a bioprosthetic valve. Data were collected from medical records and outpatient department (OPD) registers. Follow-up included transthoracic 2D echocardiography, supported by clinical parameters, and X-ray findings.
Mean age was 58.52+/-2.4 years. Follow-up period ranged from one to eleven years (mean 6.8+/-0.9 years). Immediate perioperative mortality included five patients (4.76%) and long term mortality included three patients (3%). 35 patients previously underwent closed and open commissurotomy and balloon valvotomy. Multivariate analysis showed age, repeat surgery, atrial fibrillation, tricuspid valve disease, and preoperative functional status to be incremental risk factors. Freedom from repeat operation at 3 and 6 years was 90% and 85% in group I (<60 years), respectively. Actuarial survival at 4 and 6 years of follow up was 94.24% and 88.52%, respectively.
With improving life expectancy and early interventions, the number of < or = 50-year old rheumatic valvular disease patients is increasing. The present study showed a marked improvement for this subset of patients, although age still remains the main risk factor along with atrial fibrillation, repeat surgery, stroke and tricuspid valve disease.
与过去相比,风湿性二尖瓣病患者现在更常活到五十多岁。本研究的目的是深入了解如何改善这些患者的发病率和死亡率。
这项回顾性研究纳入了105例年龄在50岁及以上的患者。其中75例行机械瓣膜置换术,30例接受生物瓣膜置换。数据从病历和门诊部(OPD)登记册中收集。随访包括经胸二维超声心动图检查,并辅以临床参数和X线检查结果。
平均年龄为58.52±2.4岁。随访期为1至11年(平均6.8±0.9年)。围手术期即刻死亡率为5例(4.76%),长期死亡率为3例(3%)。35例患者既往接受过闭式和直视交界切开术以及球囊瓣膜成形术。多因素分析显示年龄、再次手术、心房颤动、三尖瓣疾病和术前功能状态是增加风险的因素。I组(<60岁)3年和6年无再次手术的比例分别为90%和85%。随访4年和6年的精算生存率分别为94.24%和88.52%。
随着预期寿命的延长和早期干预,年龄≤50岁的风湿性瓣膜病患者数量正在增加。本研究表明该亚组患者情况有显著改善,尽管年龄仍然是主要危险因素,此外还有心房颤动、再次手术、中风和三尖瓣疾病。