伴刀豆球蛋白A的结合及其对盘基网柄菌分化的影响。
Binding of Concanavalin A and its effect on the differentiation of Dictyostelium Discoideum.
作者信息
Darmon M, Klein C
出版信息
Biochem J. 1976 Mar 15;154(3):743-50. doi: 10.1042/bj1540743.
Abstract
Dictyostelium discoideum amoebae have two classes of binding sites for concanavalin A, one accessible to a competitive inhibitor of concanavalin A binding and one inaccessible. Uptake of concanavalin A occurs and is associated with a transfer from accessible to inaccessible binding sites. Low amounts of concanavalin A bound to cells produce a slight stimulation of differentiation, and this is associated with an increase in production of phosphodiesterase. Above a critical amount of concanavalin A bound, cell differentiation and phosphodiesterase production are inhibited. The relationship of concanavalin A-induced membrane changes to cell differentation is discussed.
摘要
盘基网柄菌变形虫对伴刀豆球蛋白A有两类结合位点，一类可被伴刀豆球蛋白A结合的竞争性抑制剂所作用，另一类则不能。伴刀豆球蛋白A会发生摄取，并与从可及结合位点向不可及结合位点的转移相关。与细胞结合的少量伴刀豆球蛋白A会对分化产生轻微刺激，这与磷酸二酯酶产量的增加有关。当结合的伴刀豆球蛋白A超过临界量时，细胞分化和磷酸二酯酶的产生会受到抑制。文中讨论了伴刀豆球蛋白A诱导的膜变化与细胞分化的关系。
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