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Short-term binding and hydrolysis of cyclic 3':5'-adenosine monophosphate by aggregating Dictyostelium cells.聚集的盘基网柄菌细胞对环磷酸腺苷的短期结合与水解作用
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2423-7. doi: 10.1073/pnas.71.6.2423.
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Correlation of substrate specificity of cAMP-phosphodiesterase in Dictyostelium discoideum with chemotactic activity of cAMP-analogues.盘基网柄菌中cAMP-磷酸二酯酶的底物特异性与cAMP类似物趋化活性的相关性。
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A study on sensing and adaptation in Dictyostelium discoideum: guanosine 3',5'-phosphate accumulation and light-scattering responses.盘基网柄菌的传感与适应性研究：3',5'-环磷酸鸟苷积累及光散射反应
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本文引用的文献

1
Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture.细胞黏菌盘基网柄菌的黏变形体在无菌培养中的生长。
Biochem J. 1970 Sep;119(2):171-4. doi: 10.1042/bj1190171.
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Molecular interactions of the acetylcholine receptor.乙酰胆碱受体的分子相互作用
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Dynamics of antigenic membrane sites relating to cell aggregation in Dictyostelium discoideum.盘基网柄菌中与细胞聚集相关的抗原性膜位点的动态变化
J Cell Biol. 1973 Mar;56(3):647-58. doi: 10.1083/jcb.56.3.647.
4
Cyclic-AMP-controlled oscillations in suspended Dictyostelium cells: their relation to morphogenetic cell interactions.悬浮的盘基网柄菌细胞中由环磷酸腺苷控制的振荡：它们与形态发生细胞相互作用的关系。
Proc Natl Acad Sci U S A. 1974 May;71(5):2118-22. doi: 10.1073/pnas.71.5.2118.
5
Cyclic AMP binding to living cells of Dictyostelium discoideum in presence of excess cyclic GMP.
Biochem Biophys Res Commun. 1973 Nov 1;55(1):200-4. doi: 10.1016/s0006-291x(73)80079-8.
6
Studies on the orientation of cyclic AMP-dependent protein kinase in human erythrocyte membranes.人红细胞膜中环磷酸腺苷依赖性蛋白激酶定位的研究。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3735-8. doi: 10.1073/pnas.70.12.3735.
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The chemotactic effect of cyclic nucleotides with substitutions in the base ring.
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8
Adenosine 3':5'-cyclic monophosphate-binding protein from the cellular slime mould Dictyostelium discoideum.来自细胞黏菌盘基网柄菌的3':5'-环磷酸腺苷结合蛋白。
Biochem J. 1973 Jul;133(3):601-3. doi: 10.1042/bj1330601.
9
Correlation of substrate specificity of cAMP-phosphodiesterase in Dictyostelium discoideum with chemotactic activity of cAMP-analogues.盘基网柄菌中cAMP-磷酸二酯酶的底物特异性与cAMP类似物趋化活性的相关性。
FEBS Lett. 1973 Aug 1;34(1):5-9. doi: 10.1016/0014-5793(73)80690-8.
10
Defective cyclic adenosine-3', 5'-phosphate-phosphodiesterase regulation in morphogenetic mutants of Dictyostelium discoideum.盘基网柄菌形态发生突变体中环状腺苷 - 3',5'-磷酸磷酸二酯酶调节缺陷
J Mol Biol. 1973 Mar 15;74(4):573-85. doi: 10.1016/0022-2836(73)90048-x.

聚集的盘基网柄菌细胞对环磷酸腺苷的短期结合与水解作用

Short-term binding and hydrolysis of cyclic 3':5'-adenosine monophosphate by aggregating Dictyostelium cells.

作者信息

Malchow D, Gerisch G

出版信息

Proc Natl Acad Sci U S A. 1974 Jun;71(6):2423-7. doi: 10.1073/pnas.71.6.2423.

DOI:10.1073/pnas.71.6.2423
PMID:4366767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388469/
Abstract

Transient binding of cyclic AMP to aggregating cells of Dictyostelium discoideum was measured under cyclic GMP excess in order to inhibit cyclic AMP hydrolysis by cell-bound phosphodiesterase. Cyclic GMP extended the period of half-maximal cyclic AMP binding from less than 5 sec to 1-2 min. With the same time course as bound cyclic AMP was released from the cells, labeled 5'-AMP appeared in the medium. Specificity, kinetics, and developmental regulation suggest that the cyclic AMP-binding sites exposed in living cells are identical with receptor sites for the chemotactic response. The functioning of the cyclic AMP-receptor/phosphodiesterase system and its formal similarity with the synaptic acetylcholine-receptor/esterase system are discussed.

摘要

为了抑制细胞结合型磷酸二酯酶对环磷酸腺苷（cAMP）的水解，在过量环磷酸鸟苷（cGMP）存在的情况下，测定了cAMP与盘基网柄菌聚集细胞的瞬时结合。cGMP将cAMP半最大结合期从不到5秒延长至1 - 2分钟。与结合的cAMP从细胞中释放的时间进程相同，标记的5'-AMP出现在培养基中。特异性、动力学和发育调控表明，活细胞中暴露的cAMP结合位点与趋化反应的受体位点相同。本文讨论了cAMP受体/磷酸二酯酶系统的功能及其与突触乙酰胆碱受体/酯酶系统的形式相似性。