聚集的盘基网柄菌细胞对环磷酸腺苷的短期结合与水解作用
Short-term binding and hydrolysis of cyclic 3':5'-adenosine monophosphate by aggregating Dictyostelium cells.
作者信息
Malchow D, Gerisch G
出版信息
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2423-7. doi: 10.1073/pnas.71.6.2423.
Abstract
Transient binding of cyclic AMP to aggregating cells of Dictyostelium discoideum was measured under cyclic GMP excess in order to inhibit cyclic AMP hydrolysis by cell-bound phosphodiesterase. Cyclic GMP extended the period of half-maximal cyclic AMP binding from less than 5 sec to 1-2 min. With the same time course as bound cyclic AMP was released from the cells, labeled 5'-AMP appeared in the medium. Specificity, kinetics, and developmental regulation suggest that the cyclic AMP-binding sites exposed in living cells are identical with receptor sites for the chemotactic response. The functioning of the cyclic AMP-receptor/phosphodiesterase system and its formal similarity with the synaptic acetylcholine-receptor/esterase system are discussed.
摘要
为了抑制细胞结合型磷酸二酯酶对环磷酸腺苷（cAMP）的水解，在过量环磷酸鸟苷（cGMP）存在的情况下，测定了cAMP与盘基网柄菌聚集细胞的瞬时结合。cGMP将cAMP半最大结合期从不到5秒延长至1 - 2分钟。与结合的cAMP从细胞中释放的时间进程相同，标记的5'-AMP出现在培养基中。特异性、动力学和发育调控表明，活细胞中暴露的cAMP结合位点与趋化反应的受体位点相同。本文讨论了cAMP受体/磷酸二酯酶系统的功能及其与突触乙酰胆碱受体/酯酶系统的形式相似性。
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Short-term binding and hydrolysis of cyclic 3':5'-adenosine monophosphate by aggregating Dictyostelium cells.聚集的盘基网柄菌细胞对环磷酸腺苷的短期结合与水解作用
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Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture.细胞黏菌盘基网柄菌的黏变形体在无菌培养中的生长。
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Cyclic-AMP-controlled oscillations in suspended Dictyostelium cells: their relation to morphogenetic cell interactions.悬浮的盘基网柄菌细胞中由环磷酸腺苷控制的振荡：它们与形态发生细胞相互作用的关系。
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