Trindade Giliane S, Emerson Ginny L, Carroll Darin S, Kroon Erna G, Damon Inger K
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Emerg Infect Dis. 2007 Jul;13(7):965-72. doi: 10.3201/eid1307.061404.
Although the World Health Organization (WHO) declared global smallpox eradicated in 1980, concerns over emergent poxvirus infections have increased. Most poxvirus infections are zoonotic; exploring their genetic diversity will illuminate the genetic and evolutionary aspects of poxvirus infections, ecology, and epidemiology. In recent decades, several strains of the orthopoxvirus vaccinia virus (VACV) have been isolated throughout Brazil, including genetically distinct isolates within the same outbreak. To further investigate the diversity and origins of these viruses, we analyzed molecular data from 8 Brazilian VACV isolates and compared several genes involved in virus structure and pathogenicity. Genetic variation among isolates suggests that ancestral Brazilian VACVs existed before the beginning of the WHO smallpox eradication vaccination campaigns and that these viruses continue to circulate.
尽管世界卫生组织（WHO）于1980年宣布全球消灭了天花，但对新出现的痘病毒感染的担忧却与日俱增。大多数痘病毒感染是人畜共患病；探索它们的遗传多样性将阐明痘病毒感染、生态学和流行病学的遗传及进化方面。近几十年来，在巴西各地分离出了几种正痘病毒痘苗病毒（VACV）毒株，包括在同一疫情中具有遗传差异的分离株。为了进一步研究这些病毒的多样性和起源，我们分析了来自8株巴西VACV分离株的分子数据，并比较了几个与病毒结构和致病性有关的基因。分离株之间的遗传变异表明，巴西VACV的祖先在世卫组织天花根除疫苗接种运动开始之前就已存在，并且这些病毒仍在传播。
