Bunney B S, Chiodo L A, Grace A A
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510.
Synapse. 1991 Oct;9(2):79-94. doi: 10.1002/syn.890090202.
The pathogenesis of a variety of neurological and mental disorders has been attributed to the malfunctioning of central dopaminergic systems. Twenty years of investigation concerning the way that dopamine systems function in the brain has yielded a great deal of information about the control and behavior of these systems. This collection of seemingly disparate facts is reviewed. A hypothesis is then presented that attempts to synthesize from these facts a view of the electrophysiological functioning of midbrain dopamine systems that may be helpful in understanding brain mechanisms underlying the pathology of such disorders as Parkinson's disease and schizophrenia.
多种神经和精神障碍的发病机制被认为与中枢多巴胺能系统功能失调有关。二十年来，关于多巴胺系统在大脑中发挥作用方式的研究，已经产生了大量有关这些系统的控制和行为的信息。本文对这些看似零散的事实进行了综述。随后提出了一个假说，试图从这些事实中综合出中脑多巴胺系统电生理功能的观点，这可能有助于理解帕金森病和精神分裂症等疾病病理背后的脑机制。
