Key Peter B, Hoguet Jennifer, Reed Lou Ann, Chung Katy W, Fulton Michael H
National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Ft. Johnson Road, Charleston, SC 29412, USA.
Environ Toxicol. 2008 Apr;23(2):153-60. doi: 10.1002/tox.20318.
This study investigated lethal effects (i.e., survival) and sublethal effects (glutathione, GSH; lipid peroxidation, LPx; cholesterol, CHL; and acetylcholinesterase, AChE) of the antihyperlipidemic drug simvastatin on larval and adult grass shrimp (Palaemonetes pugio). The 96-h LC50 test for larvae resulted in an estimated LC50 of 1.18 mg/L (95% confidence interval 0.98-1.42 mg/L). The adult 96-h LC50 was >10.0 mg/L. GSH and AChE levels for both the larvae and the adults were not significantly affected by simvastatin exposure. LPx levels in the larvae were significantly higher than controls in the lowest and the highest simvastatin exposures. In adult grass shrimp, LPx levels were highest in the three lowest simvastatin exposures. CHL levels were significantly reduced in larvae at the highest simvastatin exposure level of 1 mg/L while adult CHL was not affected. Both lethal and sublethal effects associated with simvastatin exposure were only observed at concentrations well above those reported in the environment.
本研究调查了抗高血脂药物辛伐他汀对幼体和成体草虾（Palaemonetes pugio）的致死效应（即存活率）和亚致死效应（谷胱甘肽，GSH；脂质过氧化，LPx；胆固醇，CHL；以及乙酰胆碱酯酶，AChE）。幼体的96小时半数致死浓度（LC50）测试得出估计的LC50为1.18毫克/升（95%置信区间0.98 - 1.42毫克/升）。成体的96小时LC50大于10.0毫克/升。辛伐他汀暴露对幼体和成体的GSH和AChE水平均无显著影响。在最低和最高辛伐他汀暴露水平下，幼体的LPx水平显著高于对照组。在成体草虾中，LPx水平在最低的三个辛伐他汀暴露水平下最高。在最高辛伐他汀暴露水平1毫克/升时，幼体的CHL水平显著降低，而成体的CHL未受影响。与辛伐他汀暴露相关的致死和亚致死效应仅在远高于环境中报道浓度的情况下才观察到。
