Nunes H, Bagan P, Kambouchner M, Martinod E
Service de Pneumologie, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, UFR SMBH, Université Paris 13, 93009 Bobigny, France.
Rev Mal Respir. 2007 Dec;24(10):1329-40. doi: 10.1016/s0761-8425(07)78510-8.
Endometriosis is defined as the abnormal presence of endometrial tissue, including endometrial glands and stroma, outside the uterine cavity. The term "thoracic endometriosis" is classically referred to the respiratory manifestations which classically result from the presence and the cyclical changes of endometrial tissue in one of the thoracic structures.
Although thoracic endometriosis is rare, four clinical entities are well-recognized: pneumothorax, hemothorax, haemoptysis and pulmonary nodule, with a respective frequency of 73%, 14%, 7% and 6%. These are characterized by the recurrence of symptoms within the menstruations, in women aged between 30 and 40, and mainly in the right hemi-thorax. Pelvic endometriosis is usually, if not constantly, associated. Catamenial pneumothorax is not always related to thoracic endometriosis and its mechanisms remain unclear. An exploratory and therapeutical surgery is required in most of the cases. Video-assisted-thoracoscopy is the best current approach of catamenial pneumothorax. It may visualize pathognomonic pleuro-diaphragmatic abnormalities, including diaphragmatic fenestrations and/or endometrial implants, in about one third of the patients. Surgical treatment is justified because of the frequent relapses under medical treatment alone. Surgery consists of diaphragmatic repair and excision of all apparent endometrial implants; pleural abrasion may complete the procedure. A combined prolonged hormonal therapy is increasingly recommended, Danazol or GnRH analogs being advantaged.
Further prospective studies are needed to estimate the real incidence of thoracic endometriosis and to devise the best therapeutical option.
Thoracic endometriosis is probably rare but its diagnosis is easy when accurately raised. The approach is multidisciplinary involving a pneumologist, a thoracic surgeon and a gynecologist.
子宫内膜异位症的定义为子宫腔外出现异常的子宫内膜组织,包括子宫内膜腺体和间质。术语“胸腔子宫内膜异位症”传统上指的是呼吸系统表现,通常是由于胸腔结构之一中存在子宫内膜组织及其周期性变化所致。
尽管胸腔子宫内膜异位症较为罕见,但有四种临床类型已得到充分认识:气胸、血胸、咯血和肺结节,其发生率分别为73%、14%、7%和6%。这些病症的特点是在30至40岁的女性月经期间症状复发,且主要发生在右半胸。盆腔子宫内膜异位症通常(即便并非总是)与之相关。经期气胸并不总是与胸腔子宫内膜异位症相关,其发病机制仍不清楚。大多数情况下需要进行探索性和治疗性手术。电视辅助胸腔镜检查是目前治疗经期气胸的最佳方法。在约三分之一的患者中,它可以观察到特征性的胸膜-膈肌异常,包括膈肌开窗和/或子宫内膜植入物。由于单纯药物治疗频繁复发,手术治疗是合理的。手术包括膈肌修复和切除所有明显的子宫内膜植入物;胸膜摩擦术可完善手术过程。越来越推荐联合长期激素治疗,达那唑或促性腺激素释放激素类似物具有优势。
需要进一步的前瞻性研究来估计胸腔子宫内膜异位症的实际发病率,并制定最佳治疗方案。
胸腔子宫内膜异位症可能较为罕见,但一旦准确提出,其诊断并不困难。治疗方法是多学科的,涉及呼吸科医生、胸外科医生和妇科医生。