Wallin A, Carlsson A, Ekman R, Gottfries C G, Karlsson I, Svennerholm L, Widerlöv E
Department of Psychiatry and Neurochemistry, Gothenburg University, St. Jörgen's Hospital, Hisings Backa, Sweden.
Eur Neuropsychopharmacol. 1991 May;1(2):165-8. doi: 10.1016/0924-977x(91)90718-a.
The concentrations of monoamines and various neuropeptides were determined in the hypothalamus of brains from patients with Alzheimer's disease and vascular dementia (n = 26) and compared with control values (n = 21). Decreased concentrations of 5-hydroxyindoleacetic acid (P less than 0.05) and homovanillic acid (P less than 0.01) were found, and increased arginine vasopressin- (P less than 0.01), galanin- (P less than 0.05) and somatostatin- (P less than 0.01) like immunoreactivity. It is proposed that this disequilibrium may be important for certain circadian symptoms, e.g. the changes in sleep/wake rhythms that are rather often observed in dementia.
测定了阿尔茨海默病和血管性痴呆患者（n = 26）大脑下丘脑中单胺类物质和各种神经肽的浓度，并与对照值（n = 21）进行比较。发现5-羟吲哚乙酸浓度降低（P < 0.05）和高香草酸浓度降低（P < 0.01），而精氨酸加压素样免疫反应性升高（P < 0.01）、甘丙肽样免疫反应性升高（P < 0.05）和生长抑素样免疫反应性升高（P < 0.01）。有人提出，这种失衡可能对某些昼夜节律症状很重要，例如在痴呆症中经常观察到的睡眠/觉醒节律变化。
