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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nagaoka S, Arai H, Iwamoto N, Ohwada J, Ichimiya Y, Nakamura M, Inoue R

Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.

Prog Neuropsychopharmacol Biol Psychiatry. 1995 Dec;19(8):1251-61. doi: 10.1016/0278-5846(95)00264-2.

An autopsy case of frontotemporal dementia with onset at the early age of 28 years is reported. 2. The neuropathological features consisted of limited, knife-like frontotemporal atrophy with severe neuronal loss, spongiform change and gliosis, which is compatible with the frontotemporal dementia. 3. Biochemical determinations disclosed that biogenic amines and their metabolites, predominant in the dopaminergic markers, were depleted in the damaged regions. 4. Since biochemical data in frontotemporal dementia are few in previous studies, it will be determined whether these biochemical changes are characteristic for the juvenile type of frontotemporal dementia or not.

报告了一例28岁早发的额颞叶痴呆尸检病例。2. 神经病理学特征包括局限性、刀样额颞叶萎缩，伴有严重神经元丢失、海绵状改变和胶质增生，这与额颞叶痴呆相符。3. 生化测定显示，受损区域中以多巴胺能标志物为主的生物胺及其代谢产物减少。4. 由于先前研究中额颞叶痴呆的生化数据较少，因此将确定这些生化变化是否为青少年型额颞叶痴呆所特有。

Nagaoka S, Arai H, Iwamoto N, Ohwada J, Ichimiya Y, Nakamura M, Inoue R

Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.

Prog Neuropsychopharmacol Biol Psychiatry. 1995 Dec;19(8):1251-61. doi: 10.1016/0278-5846(95)00264-2.

An autopsy case of frontotemporal dementia with onset at the early age of 28 years is reported. 2. The neuropathological features consisted of limited, knife-like frontotemporal atrophy with severe neuronal loss, spongiform change and gliosis, which is compatible with the frontotemporal dementia. 3. Biochemical determinations disclosed that biogenic amines and their metabolites, predominant in the dopaminergic markers, were depleted in the damaged regions. 4. Since biochemical data in frontotemporal dementia are few in previous studies, it will be determined whether these biochemical changes are characteristic for the juvenile type of frontotemporal dementia or not.

报告了一例28岁早发的额颞叶痴呆尸检病例。2. 神经病理学特征包括局限性、刀样额颞叶萎缩，伴有严重神经元丢失、海绵状改变和胶质增生，这与额颞叶痴呆相符。3. 生化测定显示，受损区域中以多巴胺能标志物为主的生物胺及其代谢产物减少。4. 由于先前研究中额颞叶痴呆的生化数据较少，因此将确定这些生化变化是否为青少年型额颞叶痴呆所特有。