Stumpf U C, Kurth A A, Windolf J, Fassbender W J
Department of Traumatology and Handsurgery, University Hospital Duesseldorf, Heinrich Heine University, Duesseldorf, Germany.
Adv Med Sci. 2007;52:94-7.
Pregnancy-associated osteoporosis is an uncommon condition characterized by the occurrence of painful fractures during late pregnancy or lactation. To date the pathophysiology of this entity of bone disorder is still uncertain, and its therapeutical management is poorly defined. We report two clinical cases: a 10-years follow-up with pain medication and intermittent antiresorptive therapy courses, subsequent traumatic vertebral fracture and actually fracture of scaphoid after inadequate trauma. Beside this long-term course a young female patient with pregnancy-associated osteoporosis and painful lumbar and also thoracic vertebral fractures is described. She was treated with an osteoanabolic therapy, at the timepoint of first follow-up at 6 months of treatment a solid increase of bone mineral density and sustained pain reduction was observed.
妊娠相关性骨质疏松症是一种罕见的病症，其特征为在妊娠晚期或哺乳期发生疼痛性骨折。迄今为止，这种骨病实体的病理生理学仍不明确，其治疗管理也缺乏明确的定义。我们报告两例临床病例：一例进行了10年的随访，采用了止痛药物和间歇性抗吸收治疗疗程，随后发生了创伤性椎体骨折，以及在受到轻微创伤后舟状骨骨折。除了这个长期病例外，还描述了一名患有妊娠相关性骨质疏松症且伴有疼痛性腰椎和胸椎骨折的年轻女性患者。她接受了骨合成代谢治疗，在治疗6个月首次随访时，观察到骨密度显著增加且疼痛持续减轻。
