Churchyard A, Day T, Grainger K, Mastaglia F L
Department of Neurology, Queen Elizabeth II Medical Centre, Nedlands, Western Australia.
Clin Exp Neurol. 1991;28:168-79.
The inflammatory demyelinating polyneuropathies are presumed to be autoimmune diseases and as such have been treated in the past with corticosteroids, plasmapheresis and immunosuppressants. Immunoglobulin infusions represent a fourth treatment with the potential to modify the activity of the immune system in disease states. Limited past experience suggests that both acute inflammatory polyneuropathy and chronic inflammatory demyelinating polyneuropathy may respond to immunoglobulin infusions with minimal morbidity. We here outline our successful experience of this treatment in 5 of 6 patients with inflammatory demyelinating polyneuropathies and review the literature describing its use.
炎性脱髓鞘性多发性神经病被认为是自身免疫性疾病，因此过去一直使用皮质类固醇、血浆置换和免疫抑制剂进行治疗。静脉输注免疫球蛋白是第四种治疗方法，有可能改变疾病状态下免疫系统的活性。过去有限的经验表明，急性炎性多发性神经病和慢性炎性脱髓鞘性多发性神经病对静脉输注免疫球蛋白可能有反应，且发病率极低。在此，我们概述了6例炎性脱髓鞘性多发性神经病患者中5例接受这种治疗的成功经验，并回顾了描述其应用的文献。
