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二甲基亚砜对具有高丝氨酸脱氢酶活性的枯草芽孢杆菌突变体赖氨酸生产的影响。

Effect of dimethyl sulfoxide on lysine production by a mutant of Bacillus subtilis with homoserine dehydrogenase activity.

作者信息

Kalcheva H O, Shanskaya V O, Smutny J, Maluta S S

机构信息

Institute of Molecular Biology and Genetics, Kiev, USSR.

出版信息

Folia Microbiol (Praha). 1991;36(5):447-50. doi: 10.1007/BF02884064.

DOI:10.1007/BF02884064
PMID:1821870
Abstract

Some Bacillus subtilis mutants with different levels of homoserine dehydrogenase were described. Strains that do not accumulate methionine have a high homoserine dehydrogenase activity. Low activity was detected in mutants where cell growth was completely inhibited by 0.7 mmol/L methionine. A low concentration of dimethyl sulfoxide had a stimulatory effect on lysine production by the methionine-sensitive mutant of Bacillus subtilis.

摘要

描述了一些具有不同水平高丝氨酸脱氢酶的枯草芽孢杆菌突变体。不积累甲硫氨酸的菌株具有高丝氨酸脱氢酶活性。在细胞生长被0.7 mmol/L甲硫氨酸完全抑制的突变体中检测到低活性。低浓度的二甲基亚砜对枯草芽孢杆菌甲硫氨酸敏感突变体的赖氨酸生产有刺激作用。

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本文引用的文献

1
[Retro-inhibition and repression of the homoserine dehydrogenase of Escherichia coli].[大肠杆菌高丝氨酸脱氢酶的逆向抑制与阻遏]
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Reaction of ninhydrin in acid solution with straight-chain amino acids containing two amino groups and its application to the estimation of alpha epsilon-diaminopimelic acid.茚三酮在酸性溶液中与含两个氨基的直链氨基酸的反应及其在α,ε-二氨基庚二酸测定中的应用。
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枯草芽孢杆菌S-（2-氨基乙基）L-半胱氨酸抗性突变体的赖氨酸排泄
Acta Microbiol Pol. 1983;32(1):37-45.
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Subunits of the complex protein carrying the threonine-sensitive aspartokinase activity in a mutant of Escherichia coli K 12.在大肠杆菌K12的一个突变体中携带苏氨酸敏感天冬氨酸激酶活性的复合蛋白的亚基。
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Minor threonine dehydratase encoded within the threonine synthetic region of Bacillus subtilis.枯草芽孢杆菌苏氨酸合成区域内编码的次要苏氨酸脱水酶。
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Regulation of aspartate family amino acid biosynthesis in Brevibacterium flavum. I. Inhibition by amino acids of the enzymes in threonine biosynthesis.黄色短杆菌中天冬氨酸族氨基酸生物合成的调节。I. 苏氨酸生物合成中酶的氨基酸抑制作用。
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8
Regulation of enzymes of lysine biosynthesis in Corynebacterium glutamicum.谷氨酸棒杆菌中赖氨酸生物合成酶的调控
J Gen Microbiol. 1988 Dec;134(12):3221-9. doi: 10.1099/00221287-134-12-3221.
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[Mutants of Bacillus subtilis resistant to lysine analog S-2 aminoethyl-L-cysteine].
Genetika. 1989 Nov;25(11):1937-45.
10
Amino acid biosynthesis and its regulation.氨基酸生物合成及其调控。
Annu Rev Biochem. 1978;47:532-606. doi: 10.1146/annurev.bi.47.070178.002533.