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枯草芽孢杆菌S-(2-氨基乙基)L-半胱氨酸抗性突变体的赖氨酸排泄

Lysine excretion by S-(2-aminoethyl)L-cysteine resistant mutants of Bacillus subtilis.

作者信息

Chaudhuri A, Mishra A K, Nanda G

出版信息

Acta Microbiol Pol. 1983;32(1):37-45.

PMID:6194664
Abstract

S-(2-Aminoethyl)L-cysteine (AEC) at 2 X 10(-1) mM concentration completely inhibited the growth of Bacillus subtilis. This inhibitory effect was readily reversed by 2 X 10(-2) mM L-lysine. Besides L-lysine, L-aspartic acid was only effective of all the natural amino acids tested in reversing the AEC-mediated growth inhibition. AEC resistant mutants of B. subtilis were isolated and found to excrete L-lysine in high yields.

摘要

2×10⁻¹ mM浓度的S-(2-氨基乙基)-L-半胱氨酸(AEC)完全抑制枯草芽孢杆菌的生长。2×10⁻² mM的L-赖氨酸能轻易逆转这种抑制作用。除L-赖氨酸外,在所有测试的天然氨基酸中,只有L-天冬氨酸能有效逆转AEC介导的生长抑制。分离出枯草芽孢杆菌的AEC抗性突变体,发现其能高产分泌L-赖氨酸。

相似文献

1
Lysine excretion by S-(2-aminoethyl)L-cysteine resistant mutants of Bacillus subtilis.枯草芽孢杆菌S-(2-氨基乙基)L-半胱氨酸抗性突变体的赖氨酸排泄
Acta Microbiol Pol. 1983;32(1):37-45.
2
[Mutants of Bacillus subtilis resistant to lysine analog S-2 aminoethyl-L-cysteine].
Genetika. 1989 Nov;25(11):1937-45.
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Production of L-arginine by arginine hydroxamate-resistant mutants of Bacillus subtilis.枯草芽孢杆菌精氨酸异羟肟酸盐抗性突变体产L-精氨酸
Appl Microbiol. 1971 Dec;22(6):987-91. doi: 10.1128/am.22.6.987-991.1971.
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Regulation of dihydrodipicolinate synthase and diaminopimelate decarboxylase activity in Bacillus stearothermophilus.
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Effect of dimethyl sulfoxide on lysine production by a mutant of Bacillus subtilis with homoserine dehydrogenase activity.二甲基亚砜对具有高丝氨酸脱氢酶活性的枯草芽孢杆菌突变体赖氨酸生产的影响。
Folia Microbiol (Praha). 1991;36(5):447-50. doi: 10.1007/BF02884064.
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Participation of lysine-sensitive aspartokinase in threonine production by S-2-aminoethyl cysteine-resistant mutants of Serratia marcescens.赖氨酸敏感天冬氨酸激酶在粘质沙雷氏菌S-2-氨基乙基半胱氨酸抗性突变体苏氨酸生产中的作用
Appl Environ Microbiol. 1979 Nov;38(5):777-82. doi: 10.1128/aem.38.5.777-782.1979.
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beta-lactam antibiotic production by Streptomyces clavuligerus mutants impaired in regulation of aspartokinase.克拉维链霉菌中天冬氨酸激酶调控受损的突变体产生β-内酰胺抗生素的情况
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[Isolation and analysis of strains of Streptococcus faecium and Streptococcus bovis resistant to S-(2-aminoethyl)-L-cysteine].
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Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction.消除枯草芽孢杆菌生物素途径中的一个瓶颈:bioA在KAPA到DAPA的反应中利用赖氨酸而非S-腺苷甲硫氨酸作为氨基供体。
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Nonorthologous replacement of lysyl-tRNA synthetase prevents addition of lysine analogues to the genetic code.赖氨酰 - tRNA合成酶的非直系同源替换可防止将赖氨酸类似物添加到遗传密码中。
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14351-6. doi: 10.1073/pnas.2036253100. Epub 2003 Nov 17.

引用本文的文献

1
Improving the regeneration rate of deep lethal mutant protoplasts by fusion to promote efficient L-lysine fermentation.通过融合提高深致死突变原生质体的再生率,以促进高效 L-赖氨酸发酵。
BMC Biotechnol. 2023 Jul 14;23(1):22. doi: 10.1186/s12896-023-00792-8.
2
L-lysine production by S-2-aminoethyl-L-cysteine-resistant mutants of Arthrobacter globiformis.球形节杆菌对S-2-氨基乙基-L-半胱氨酸抗性突变体生产L-赖氨酸
Folia Microbiol (Praha). 1991;36(1):59-66. doi: 10.1007/BF02935823.
3
Effect of dimethyl sulfoxide on lysine production by a mutant of Bacillus subtilis with homoserine dehydrogenase activity.
二甲基亚砜对具有高丝氨酸脱氢酶活性的枯草芽孢杆菌突变体赖氨酸生产的影响。
Folia Microbiol (Praha). 1991;36(5):447-50. doi: 10.1007/BF02884064.