Bodemann Brian O, White Michael A
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Nat Rev Cancer. 2008 Feb;8(2):133-40. doi: 10.1038/nrc2296.
A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB as key offenders in the subversion of core biological systems driving oncogenic transformation. Here, we will focus on current developments highlighting the pivotal contribution of Ral proteins to the regulatory framework supporting tumorigenesis, and evaluate mechanistic connections between Ral effector activation and generation of this framework.
最近的一系列观察结果表明，Ras家族G蛋白RALA和RALB是颠覆驱动致癌转化的核心生物系统的关键因素。在此，我们将聚焦于当前的研究进展，这些进展突出了Ral蛋白对支持肿瘤发生的调控框架的关键贡献，并评估Ral效应器激活与该框架生成之间的机制联系。
