[Effect of thymoleptics on hemodynamic indicators and prediction of the effectiveness of the treatment of endogenous depression].

In 92 patients (22 females and 70 males) with unipolar affective disorder hemodynamic studies using a radiocardiographic method were performed during treatment of a depressed phase of illness with amitriptyline or doxepin or mianserin. Frequent presentation of hemodynamic disturbances (increased heart rate and increased blood pressure) in the course of endogenous depression was noticed. Thymoleptic treatment causes the disturbances to alter in a statistically significant manner which allows to predict the final treatment outcome. Total Peripheral Resistance Index (TPRI) reveals the highest prognostic potential.