Walecka W, Habrat E
II Kliniki Psychiatrycznej Instytutu Psychiatrii i Neurologii.
Psychiatr Pol. 1991 May-Aug;25(3-4):96-104.
Studies conducted on a group of 27 patients with endogenous depression demonstrated that measurements of dynamics of changes in memory function, attention concentration and task performance during administration of antidepressants have only a limited potential for prediction of the treatment efficiency. No significant differences in successive tests of memory function during drug administration were observed in a subgroup of patients responding positively to antidepressant treatment (subgroup R). In a subgroup of nonresponders (subgroup NR) a worsening of results of memory tests following a sleepless night lasted longer. In tests of attention concentration the subgroup R have shown a gradual improvement of results in successive test and the subgroup NR displayed a significant improvement of results in these tests only after 42 days of treatment. In the Kraepelin's test both groups displayed a significant improvement of results in relation to their baseline level, however the improvement was more pronounced in the subgroup R. The dynamics of changes of cognitive functioning in patients with endogenous depression did not reveal any linear association with the reduction of depressive symptoms.
对一组27名内源性抑郁症患者进行的研究表明，在使用抗抑郁药期间对记忆功能、注意力集中程度和任务表现的变化动态进行测量，对治疗效果的预测潜力有限。在对抗抑郁治疗有积极反应的患者亚组（R亚组）中，在药物治疗期间连续进行的记忆功能测试中未观察到显著差异。在无反应者亚组（NR亚组）中，一夜未眠后记忆测试结果的恶化持续时间更长。在注意力集中测试中，R亚组在连续测试中结果逐渐改善，而NR亚组仅在治疗42天后这些测试结果才有显著改善。在克雷佩林测试中，两组相对于其基线水平结果均有显著改善，但R亚组的改善更为明显。内源性抑郁症患者认知功能变化的动态与抑郁症状的减轻未显示出任何线性关联。
