Banerji Aleena, Sloane David E, Sheffer Albert L
Division of Rheumatology, Immunology and Allergy, Harvard Medical School/Massachusetts General Hospital, Boston, Massachusetts, USA.
Ann Allergy Asthma Immunol. 2008 Jan;100(1 Suppl 2):S19-22. doi: 10.1016/s1081-1206(10)60582-0.
To provide a summary of the literature regarding the use of attenuated androgens during the past 40 to 50 years for the treatment of hereditary angioedema (HAE).
MEDLINE and PubMed were searched to identify studies involving the treatment of HAE with androgens.
Studies were selected based on their relevance to the use of androgens for the treatment of HAE.
Attenuated androgens have proven successful for the short- and long-term treatment of HAE. Adverse effects are still concerning, and their use in children and pregnant women must be undertaken with great caution. Scheduled monitoring of liver function tests and lipid profiles in patients treated with these medications is critical.
Attenuated androgens have been successful in the short- and long-term treatment of HAE, and they are still the most frequently used medications in the United States for the treatment of this disease. There is a lack of readily available options for the treatment of acute HAE attacks apart from the administration of fresh frozen plasma or safe prophylactic therapies; however, several appropriate agents currently in clinical trials in the United States appear promising.
总结过去40至50年间关于使用减毒雄激素治疗遗传性血管性水肿（HAE）的文献。
检索MEDLINE和PubMed以识别涉及用雄激素治疗HAE的研究。
根据其与使用雄激素治疗HAE的相关性选择研究。
减毒雄激素已被证明对HAE的短期和长期治疗有效。不良反应仍然令人担忧，在儿童和孕妇中使用时必须极其谨慎。对接受这些药物治疗的患者定期监测肝功能测试和血脂谱至关重要。
减毒雄激素在HAE的短期和长期治疗中取得了成功，并且它们仍然是美国治疗这种疾病最常用的药物。除了输注新鲜冷冻血浆或安全的预防性治疗外，目前缺乏治疗急性HAE发作的现成选择；然而，美国目前正在进行临床试验的几种合适药物似乎很有前景。
