苏门答腊红豆杉中的紫杉烷二萜酯类化合物塔苏马托醇U-Z。

Tasumatrols U-Z, taxane diterpene esters from Taxus sumatrana.

作者信息

Shen Ya-Ching, Wang Shih-Sheng, Chien Ching-Te, Kuo Yao-Haur, Khalil Ashraf Taha

机构信息

School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan.

出版信息

J Nat Prod. 2008 Apr;71(4):576-80. doi: 10.1021/np078016r. Epub 2008 Jan 26.

DOI:10.1021/np078016r

PMID:18220355

Abstract

Phytochemical investigation of the leaves and twigs of Taxus sumatrana afforded six new taxane diterpene esters, tasumatrols U-Z ( 1- 6). Compounds 2 and 5 contained a rare five-membered lactone ring at C-8, C-9, C-10, and C-19. The structures were established on the basis of detailed spectroscopic analyses, particularly HRESIMS and 2D NMR techniques. Compound 5 showed cytotoxicity against a human hepatoma (Hep2) cell line.

摘要

对苏门答腊红豆杉的叶子和嫩枝进行植物化学研究，得到了六种新的紫杉烷二萜酯，即苏门答腊醇U-Z（1-6）。化合物2和5在C-8、C-9、C-10和C-19处含有一个罕见的五元内酯环。这些结构是基于详细的光谱分析确定的，特别是高分辨电喷雾电离质谱（HRESIMS）和二维核磁共振（2D NMR）技术。化合物5对人肝癌（Hep2）细胞系显示出细胞毒性。