Koppang E O, Fischer U, Satoh M, Jirillo E
Section of Anatomy and Pathology, Institute of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway.
Curr Pharm Des. 2007;13(36):3649-55. doi: 10.2174/138161207783018644.
Modern bony fishes or teleosts are increasingly being used as model organisms for human diseases. Ambitious mapping programmes have revealed parts of or entire genomes of several species. This information suggests that there are several similarities between the mammalian and teleost immune systems, but also important differences. These differences are especially evident in the anatomical and functional constructions. However, compared to mammals, morphological studies of the immune system and in particular the inflammatory responses in fish are scarce, much due to a general lack of good cell markers. This review seeks to give an overview of the current knowledge of the teleost immune system related to inflammation and morphological research. The emphasis is placed on coronary changes which may be observed in salmonids over the size of 10 cm. Here, the immunopathological picture has some resemblance to that observed in similar changes in humans.
