Stratford N, Britten K, Gallagher P
Atherosclerosis. 1986 Mar;59(3):271-6. doi: 10.1016/0021-9150(86)90122-x.
The nature and density of coronary arterial inflammatory infiltrates were studied in autopsy material from 53 patients with no clinical or pathological evidence of ischaemic heart disease and from 22 acute cardiac deaths. Adventitial aggregates of inflammatory cells were present in 46% of cases and were slightly more frequent in arteries from patients with ischaemic heart disease. The majority of these cells were lymphocytes and immunohistochemical studies with monoclonal antibodies indicated that both B and T cells were present. Staining with polyclonal antibodies to macrophage antigens confirmed that some adventitial cells were macrophages. The reactions of foam cells within the atheromatous plaques were extremely variable but some foam cells gave unequivocably positive reactions with macrophage antibodies. There was a good overall correlation between the numbers of intimal and medial foam cells and the density of the adventitial lymphocytic infiltrates. It is suggested that these infiltrates develop as a secondary feature of atheromatous lesions and are unlikely to play a major role in their initiation or in the development of complications.
在53例无缺血性心脏病临床或病理证据的患者以及22例急性心源性死亡患者的尸检材料中，研究了冠状动脉炎性浸润的性质和密度。46%的病例存在外膜炎性细胞聚集，且在缺血性心脏病患者的动脉中略为常见。这些细胞大多数为淋巴细胞，用单克隆抗体进行的免疫组织化学研究表明，B细胞和T细胞均有存在。用针对巨噬细胞抗原的多克隆抗体染色证实，一些外膜细胞为巨噬细胞。动脉粥样硬化斑块内的泡沫细胞反应极为多样，但一些泡沫细胞对巨噬细胞抗体呈明确阳性反应。内膜和中膜泡沫细胞数量与外膜淋巴细胞浸润密度之间总体相关性良好。提示这些浸润是动脉粥样硬化病变的继发特征，不太可能在病变起始或并发症发展中起主要作用。
