Sharma Sudha, Sommers Joshua A, Brosh Robert M
Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
Protein Pept Lett. 2008;15(1):89-102. doi: 10.2174/092986608783330369.
Processing of DNA replication and repair intermediates is a critical aspect of genome stability maintenance. The coordinated action of RecQ-like helicases with structure-specific nucleases such as Flap Endonuclease 1 plays an important role in the processing of certain DNA structures associated with the replication fork, DNA repair, or telomeres. We will summarize our current understanding of how and in what context these interactions take place, with a particular emphasis on the mechanisms of RecQ helicases in processing of key DNA replication and repair intermediates by their protein interactions with FEN-1 and related structure-specific nucleases.
DNA复制和修复中间体的处理是维持基因组稳定性的关键方面。类RecQ解旋酶与诸如瓣状核酸内切酶1等结构特异性核酸酶的协同作用，在处理与复制叉、DNA修复或端粒相关的某些DNA结构中发挥重要作用。我们将总结目前对这些相互作用如何以及在何种背景下发生的理解，特别强调RecQ解旋酶通过与FEN-1及相关结构特异性核酸酶的蛋白质相互作用来处理关键DNA复制和修复中间体的机制。
