参与DNA修复、重组和复制的人类RecQ解旋酶
Human RecQ helicases in DNA repair, recombination, and replication.
作者信息
Croteau Deborah L, Popuri Venkateswarlu, Opresko Patricia L, Bohr Vilhelm A
机构信息
Laboratory of Molecular Gerontology, National Institute on Aging, Baltimore, Maryland 21224; email:
出版信息
Annu Rev Biochem. 2014;83:519-52. doi: 10.1146/annurev-biochem-060713-035428. Epub 2014 Mar 3.
Abstract
RecQ helicases are an important family of genome surveillance proteins conserved from bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome maintenance and stability, and the RecQ protein family members are often referred to as guardians of the genome. The importance of these proteins in cellular homeostasis is underscored by the fact that defects in BLM, WRN, and RECQL4 are linked to distinct heritable human disease syndromes. Each human RecQ helicase has a unique set of protein-interacting partners, and these interactions dictate its specialized functions in genome maintenance, including DNA repair, recombination, replication, and transcription. Human RecQ helicases also interact with each other, and these interactions have significant impact on enzyme function. Future research goals in this field include a better understanding of the division of labor among the human RecQ helicases and learning how human RecQ helicases collaborate and cooperate to enhance genome stability.
摘要
RecQ解旋酶是一类重要的基因组监测蛋白，从细菌到人类都保守存在。人类的五种RecQ解旋酶各自在基因组维持和稳定性方面发挥着关键作用，RecQ蛋白家族成员常被称为基因组守护者。BLM、WRN和RECQL4的缺陷与不同的遗传性人类疾病综合征相关，这一事实凸显了这些蛋白在细胞稳态中的重要性。每种人类RecQ解旋酶都有一组独特的蛋白质相互作用伙伴，这些相互作用决定了其在基因组维持中的特殊功能，包括DNA修复、重组、复制和转录。人类RecQ解旋酶之间也会相互作用，这些相互作用对酶的功能有重大影响。该领域未来的研究目标包括更好地理解人类RecQ解旋酶之间的分工，以及了解人类RecQ解旋酶如何协作以增强基因组稳定性。
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